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Throughout the Office regarding Epidemiology, Agencies from Medicine (Yards.A good.M., T.Grams., M.M.) and Agency out-of Nutrients and Integrative Anatomy (P.M.G.), College or university away from Utah, Salt Lake Urban area; Company out-of Medicine, New york College or university College out-of Medication (J.Meters.B.); Welch Center getting Prevention, Epidemiology and you will Health-related Browse, Johns Hopkins School, Baltimore, MD (L.J.A beneficial.); and you will Agencies regarding Biostatistical Sciences, Aftermath Forest College or university out-of Medicine, Winston-Salem, NC (J.An excellent.T.).
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From the Department out-of Epidemiology, Company regarding Treatments (M.Good.M., T.G., M.Yards.) and Institution of Nutrition and you may Integrative Structure (P.M.G.), College regarding Utah, Sodium Lake Area; Agency out-of Treatments, Ny College or university College regarding Treatments (J.Meters.B.); Welch Cardio for Cures, Epidemiology and you may Logical Browse, Johns Hopkins University, Baltimore, MD (L.J.An excellent.); and https://www.datingranking.net/clover-dating-review/ you can Agency out of Biostatistical Sciences, Wake Forest College or university regarding Drug, Winston-Salem, NC (J.A beneficial.T.).
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From the Division off Epidemiology, Agency of Medication (Meters.A good.Yards., T.Grams., Yards.Yards.) and you will Company out-of Nutrients and you may Integrative Anatomy (P.Yards.Grams.), School of Utah, Salt River Area; Agency regarding Drug, Ny University School of Medication (J.Yards.B.); Welch Cardiovascular system to have Prevention, Epidemiology and Systematic Search, Johns Hopkins University, Baltimore, MD (L.J.A good.); and you can Agencies from Biostatistical Sciences, Aftermath Forest College or university out-of Drug, Winston-Salem, NC (J.An excellent.T.).
You’re enjoying the most up-to-date brand of this particular article. Previous versions:
Regarding Section away from Epidemiology, Department of Medication (Meters.A great.M., T.Grams., M.M.) and you may Institution of Nourishment and Integrative Structure (P.M.G.), College out-of Utah, Salt Lake Town; Department out-of Drug, New york School College or university regarding Treatments (J.M.B.); Welch Cardiovascular system to possess Prevention, Epidemiology and you may Clinical Look, Johns Hopkins College, Baltimore, MD (L.J.Good.); and Institution out of Biostatistical Sciences, Wake Tree University regarding Drug, Winston-Salem, NC (J.A good.T.).
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Throughout the Department out-of Epidemiology, Service of Treatments (Yards.A great.Yards., T.Grams., Meters.Meters.) and you can Service from Diet and Integrative Anatomy (P.M.G.), College or university of Utah, Sodium River City; Institution of Medication, Ny College or university College or university from Medicine (J.Meters.B.); Welch Center to possess Reduction, Epidemiology and you can Logical Look, Johns Hopkins University, Baltimore, MD (L.J.Good.); and you will Agencies from Biostatistical Sciences, Wake Forest College regarding Drug, Winston-Salem, NC (J.An excellent.T.).
You’re enjoying the newest type of this informative article. Previous versions:
Regarding Section regarding Epidemiology, Service away from Treatments (Meters.A.Yards., T.G., Yards.Meters.) and Agencies regarding Diet and Integrative Anatomy (P.Yards.G.), School from Utah, Salt River Town; Department regarding Medicine, Nyc College or university School out of Treatments (J.Yards.B.); Welch Cardio having Cures, Epidemiology and you can Systematic Research, Johns Hopkins College, Baltimore, MD (L.J.An excellent.); and you can Service regarding Biostatistical Sciences, Aftermath Forest University of Treatments, Winston-Salem, NC (J.An effective.T.).
You’re watching the newest particular this informative article. Earlier incarnations:
Throughout the Department off Epidemiology, Agency out of Drug (M.A.Yards., T.G., Yards.Yards.) and you can Department regarding Nourishment and Integrative Structure (P.M.Grams.), College from Utah, Salt Lake Urban area; Institution out of Drug, Ny University College or university from Drug (J.Yards.B.); Welch Heart to have Cures, Epidemiology and you may Medical Research, Johns Hopkins School, Baltimore, MD (L.J.A beneficial.); and Institution out of Biostatistical Sciences, Wake Tree College or university out-of Drug, Winston-Salem, NC (J.A great.T.).
Abstract
Dietary Na recommendations are expressed as absolute amounts (mg/d) rather than as Na density (mg/kcal). Our objective was to determine whether the strength of the relationship of Na intake with blood pressure (BP) varied with energy intake. The DASH (Dietary Approaches to Stop Hypertension)–Sodium trial was a randomized feeding trial comparing 2 diets (DASH and control) and 3 levels of Na density. Participants with pre- or stage 1 hypertension consumed diets for 30 days in random order; energy intake was controlled to maintain body weight. This secondary analysis of 379 non-Hispanic black and white participants used mixed-effects models to assess the association of Na and energy intakes with BP. The relationships between absolute Na and both systolic and diastolic BP varied with energy intake. BP rose more steeply with increasing Na at lower energy intake than at higher energy intake (P interaction<0.001). On the control diet with 2300 mg Na, both systolic and diastolic BP were higher (3.0 mm Hg; 95% confidence interval, 0.2–5.8; and 2.7 mm Hg; 95% confidence interval, 1.0–4.5, respectively) among those with lower energy intake (higher Na density) than among those with higher energy intake (lower Na density). The association of Na with systolic BP was stronger at lower levels of energy intake in both blacks and whites (P<0.001). The association of Na and diastolic BP varied with energy intake only among blacks (P=0.001). Sodium density should be considered as a metric for expressing dietary Na recommendations.
